Bone Abstracts

We found that miR-335 is reduced in SBC-5, a human lung cancer (LC) derived cell lines inducing osteoclast formation by expressing RANKL; reviving miR-335 expression in SBC-5 results in decrease of its proliferation, invasion, migration and clone formation in vitro; reviving miR-335 expression in LC model leads to reduction of bone metastasis (BM) in vivo. It was confirmed that miR-335, inhibiting the formation and activity of osteoclasts and reducing the pro...

Objective: To comparing the role of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) in fat and bone communication.Methods: Male wild type (WT) mice, IL-6 knockout (IL-6−/−) mice, and tumor necrosis factor alpha (TNF-α) were fed with either standard diet (SD) or high fat diet (HFD) for 12 weeks. Bone mass and bone microstructure were evaluated by micro-CT. Gene expression related to lipid and bone metabolisms ...